Cisco Secure Endpoint is listed under EDR and XDR by Cisco. The 12 alternatives below are listed in the same category and are compared on starting price, features and reviews from other MSPs.
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Bitdefender GravityZone Unified EDR, XDR and MDR in one cloud console with consumption-based MSP pricing. 
Microsoft Defender for Business Endpoint security for small businesses, from $3 per user per month or included in Microsoft 365. Cisco Secure Endpoint vs Microsoft Defender for Business
Todyl A single agent bundling SASE, EDR, SIEM and MXDR, sold in three tiers priced on request. 
Elastic Security Open-source SIEM and EDR platform with behavioral detection, threat hunting, and automated response. Microsoft Defender for Endpoint Enterprise EDR bundled with Microsoft 365 E5, with multi-tenant management for MSPs via Lighthouse. Cisco Secure Endpoint vs Microsoft Defender for Endpoint
CrowdStrike Falcon Cloud-native EDR with behavioral detection, threat hunting and managed response via OverWatch. Cisco Secure Endpoint vs CrowdStrike Falcon
FortiEDR Endpoint detection and response integrated with the Fortinet Security Fabric, quote-only pricing. 
ESET PROTECT Prevention-focused endpoint detection and response with cloud or on-premises deployment. 
Cortex XDR Cross-domain XDR for endpoint investigation and response with 24/7 managed detection services. 
Huntress Managed detection and response for MSPs, priced per endpoint from $7.99 a month direct. Cisco Secure Endpoint vs Huntress
N-able Managed EDR 24/7 SOC monitoring and response for N-able's EDR agent, sold by quote, not published pricing. | Feature | Cisco Secure Endpoint | Bitdefender GravityZone | Microsoft Defender for Business | Todyl | Elastic Security | Microsoft Defender for Endpoint | CrowdStrike Falcon |
|---|---|---|---|---|---|---|---|
| Behavioural detection | yes | yes | yes | yes | yes | yes | yes |
| Automated remediation | yes | yes | yes | yes | yes | yes | yes |
| Rollback to pre-attack state | unknown | unknown | unknown | unknown | unknown | unknown | unknown |
| USB and device control | yes | yes | yes | unknown | unknown | yes | yes |
| Application allow-listing | unknown | unknown | yes | unknown | unknown | yes | yes |
| Offline protection | unknown | unknown | no | unknown | unknown | unknown | unknown |
| Threat hunting console | yes | yes | no | yes | yes | yes | yes |
| Managed MDR add-on | unknown | yes | no | yes | no | no | yes |
| SIEM and SOAR integration | unknown | unknown | yes | yes | yes | yes | yes |
| RMM integration | unknown | unknown | no | unknown | unknown | yes | yes |
| macOS support | yes | yes | yes | yes | yes | yes | yes |
| Linux support | unknown | yes | no | no | yes | yes | yes |
Bitdefender GravityZone, which matches 5 of the 5 features Cisco Secure Endpoint supports.
Elastic Security has a free version.
