Proofpoint 365 Total Protection is listed under Email security by Proofpoint. The 12 alternatives below are listed in the same category and are compared on starting price, features and reviews from other MSPs.
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Microsoft Defender for Office 365 Microsoft 365 email security against phishing and malware, priced per user per month. Proofpoint 365 Total Protection vs Microsoft Defender for Office 365
Sophos Email Cloud email security for Microsoft 365 and Google Workspace with post-delivery remediation. 
Vade AI email security for Microsoft 365 with bundled contextual security awareness training. 
Mimecast Secure email gateway, continuity, archiving and Engage awareness training, priced only on request. 
Barracuda Email Protection Cloud email security, archiving and awareness training bundled into three tiers, priced by quote only. 
SpamTitan Cloud and on-premises email security blocking phishing and malware, priced per user from $1.26 per month. Proofpoint 365 Total Protection vs SpamTitan
Hornetsecurity 365 Total Protection M365 email security, backup and compliance suite from Hornetsecurity, part of Proofpoint, quote-only. 
TrendAI Email Security Cloud email protection with AI-driven phishing and malware detection, DLP, and Microsoft 365 integration. 
Trustifi Email security with inbound filtering, outbound encryption and DLP, priced per mailbox. Proofpoint 365 Total Protection vs Trustifi
Check Point Email Security API-based email and collaboration security from Avanan, quoted through Check Point partners. 
Guardz Unified MDR, endpoint, email and identity security for MSPs, priced per user on request. 
IRONSCALES API-based phishing and BEC protection for Microsoft 365 and Google Workspace, quote-based. | Feature | Proofpoint 365 Total Protection | Microsoft Defender for Office 365 | Sophos Email | Vade | Mimecast | Barracuda Email Protection | SpamTitan |
|---|---|---|---|---|---|---|---|
| Phishing and malware filtering | yes | yes | yes | yes | yes | yes | yes |
| Spoofing and impersonation protection | yes | yes | yes | yes | yes | yes | yes |
| Email continuity | yes | yes | yes | unknown | yes | unknown | yes |
| Archiving | yes | yes | yes | yes | yes | yes | yes |
| Security awareness training bundle | yes | yes | yes | yes | yes | yes | unknown |
| API-based post-delivery scanning | yes | yes | yes | yes | yes | yes | yes |
| DMARC monitoring | yes | yes | yes | yes | yes | yes | yes |
| Attachment sandboxing | yes | yes | yes | yes | yes | yes | yes |
| Data loss prevention | yes | yes | yes | yes | unknown | yes | yes |
| Email encryption | yes | yes | yes | yes | yes | yes | yes |
| Microsoft 365 integration | yes | yes | yes | yes | yes | yes | yes |
| Self-service quarantine | unknown | yes | yes | unknown | unknown | unknown | yes |
Microsoft Defender for Office 365, which matches 11 of the 11 features Proofpoint 365 Total Protection supports.
